What age and body weight does my dog need to be before I can apply VECTRA 3D?

VECTRA 3D can be used on puppies as young as 7 weeks of age or > 4.6kg BW.

Can VECTRA 3D be used on pets other than dogs?

No. Do not use VECTRA 3D on cats, or any other animal.

How does VECTRA 3D control immature stages of fleas?

Immature stages of fleas are hidden in the environment. Inside the house, they are mainly located where the pet sleepS. Flea eggs fall off the animal and develop into larvae. Flea larvae avoid light and live on flea dirt.
They move in random directions but not more than 30-50cm from where the eggs are dropped. Pyriproxyfen is a highly potent IGR: it is active at a very low concentration. It disseminates from the treated dog (hairs, skin debris, dust, etc.) and disrupts (as a hormone) the development OF the immature stages of the fleas. This kills immature fleas, thus preventing emergence of new adults. As demonstrated (Bouhsira et al., 2012), it also sterilizes adult female fleas ready to lay eggs that are exposed to treated dogs, which prevents egg-laying.

How does VECTRA 3D kill fleas and ticks on my dog?

VECTRA 3D protects because of the triple-action formula of Dinotefuran, Pyriproxifen and Permethrin. These ingredients work together to kill fleas and ticks on contact and repel these dangerous parasites.

Once they land on your dog, the parasites come into contact with the treated skin and hairs. The more they move on the dog to find a location for biting, the more they are exposed to the active ingredients of VECTRA 3D and the
sooner they are impacted.

In ticks, VECTRA 3D first causes a “hot foot” reaction. The sensors in the legs of these parasites are highly susceptible to permethrin and make the parasite run off the dog. They are physically compelled to crawl back up the fur, away from the skin, without biting.

In fleas, VECTRA 3D quickly disrupts the feeding behavior. Within 5 min after infestation and once the product has translocated, feeding is strongly reduced as compared to untreated dogs. Fleas are quickly knocked-down and start falling off the animal without possible recovery, thanks to the synergy between dinotefuran and permethrin.

Should I remove ticks I see on my dog before applying VECTRA 3D?

Yes. The sooner ticks are removed from your dog, the better you prevent the transmission of pathogens to your dogs.
Use an appropriate tick removal device. Be sure to remove the entire body of the tick, including mouth parts.

How quickly does VECTRA 3D begins to work?

Clinical studies have shown that on dogs treated with the active ingredients in VECTRA 3D, flea feeding is reduced within five minutes and fleas are killed in the first hours - 6 hours for untreated dogs with flea infestations (therapeutic) and 2 hours for dogs that have been treated previously (residual).

VECTRA 3D is efficient against ticks 48 hours after it has been applied. If a tick infests the dog one day after administration, it will be killed within 24 hours.

Onset of activity is also very rapid against flying insects and VECTRA 3D repels sand flies, mosquitoes and biting flies 24 h after administration.

Are there possible interactions with other medicinal products?

No, there are no known interactions.

Do parasites have to bite in order for VECTRA 3D to work?

No. VECTRA 3D kills parasites through contact with your pet’s fur. No biting by the parasite is necessary.

If a cat is accidentally exposed to VECTRA 3D, what should I do?

If a cat is accidentally administered VECTRA 3D, or if it is exposed to VECTRA 3D from a treated dog and signs are evident, the following is recommended:

If administered directly to a cat, bathe the cat to remove any residual product. Dry the cat well and maintain body temperature. Seek veterinary advice immediately.

Do not administer atropine. Control hyperthermia or hypothermia. Cats may have hyperthermia initially due to tremors/seizures, but can become hypothermic if sedated with anti-convulsants and bathed. Hypothermia may worsen
the signs of permethrin toxicosis. Place cats on fluids, maintain hydration and nutrition. Recovery is usually within 24-72 hours. Call your veterinary poison center.

Why should I worry about immature fleas?

While immature fleas do not feed on the animals, they represent a large proportion of a flea population and will develop into new adults ready for infestation.

Is it okay to apply VECTRA 3D more than once a month?

No, only apply VECTRA 3D once in a 30-day period. It is not necessary for more frequent applications - VECTRA 3D provides powerful protection against fleas and ticks for a full month.

In studies performed on beagle puppies, VECTRA 3D was applied safely every two weeks during 13 consecutive weeks.

Can I brush my dog after applying VECTRA 3D?

Yes. VECTRA 3D remains effective after repeated combing of dogs. However, to reduce your own exposure to the actives, it is recommended not to brush or comb your dog until the application site is dry.

Is it okay for my pet to bathe or swim after applying VECTRA 3D?

Yes. VECTRA 3D remains effective in controlling fleas and ticks for a full month if your pet is immersed in water through swimming or bathing. However, for full and sustainable efficacy and for the protection of the environment, it is preferred not to bath or immerse your dog in water until the application site is dry. This may take up to several hours but it is highly variable according to temperature and air exposure. In the studies performed in controlled conditions, the first bathing occurred 48 h after administration and was weekly repeated without reduction of the efficacy against fleas or ticks. To protect the environment, we do not recommended a treated dog enters surface water sources (rivers, streams, sea) for 48 hours after treatment to avoid adverse effects on aquatic organisms.

What should I do if my dog exhibits unexpected signs after VECTRA 3D administration?

Transient skin redness, itching or other signs of discomfort at the application site have been reported rarely. These usually disappear without any treatment and within 24 hours after using the veterinary medicine.

Behavioural disorders such as hyperactivity, vocalization or anxiety, systemic signs such as lethargy or anorexia, and neurological signs such as muscle tremor have been reported in rare cases. Signs of ataxia such as unsteady movement have been reported in very rare cases.

Gastrointestinal (stomach or gut) adverse reactions, such as vomiting or diarrhea, have also been reported very rarely.

Transient cosmetic effects (wet appearance, spiking of hair coat and deposits) at the application site have been reported very rarely, however these effects are usually not noticeable after 48 hours.

Ask your veterinarian for advice if you are concerned about any of the aforementioned.

What should I do if my dog licks itself?

Do not worry. VECTRA 3D was administered orally at 5 times the maximal dose on young dogs (7-8 weeks) without adverse effect other than salivation and vomiting. However, to optimize the duration of efficacy of VECTRA 3D, we recommend you to distract your dog after administration, while VECTRA 3D dries.

When is the best time for VECTRA 3D administration?

We advise you to administer VECTRA 3D at the end of the day and/or preferentially before taking your dog for a walk.

Once applied, VECTRA 3D translocates on the dog’s skin and this can lead to unusual sensations for your pet. If your animal is distracted or sleeping while this phenomenon takes place, this will make him more comfortable.

Moreover, the product will start drying during the night, thus reducing the possibilities of human exposure.

What are the contraindications of VECTRA 3D?

VECTRA 3D is clearly contraindicated for cats. Due to their unique physiology and inability to metaboliZe permethrin, VECTRA 3D must not be used on cats.

If applied to a cat, or ingested by a cat that actively grooms a recently treated dog, VECTRA 3D may have serious harmful effects. If this occurs, contact your veterinarian immediately.

VECTRA 3D is also contraindicated in animals with known hypersensitivity to any of the active substances or to any of the excipients.

What if VECTRA 3D comes into contact with delicate fabrics or materials?

VECTRA 3D can stain some susceptible fabrics and other materials. We recommend administering VECTRA 3D outside or in a room away from susceptible surfaces. You should wait until the application site is dry before allowing your dog to come into contact with susceptible materials or surfaces. Make sure that your dog does not shake himself after administration. If VECTRA 3D does come into contact with delicate materials then use an absorbent cloth to remove as much of the product as possible before cleaning the surface appropriately.

What happens to the active ingredients once VECTRA 3D is applied?

Following topical application of VECTRA 3D, the actives move/translocate from the application site to cover the entire body surface within the first few hours. All active ingredients are detectable within the first day after administration in the different parts of the dog body and remain detectable for one month.

After topical application of VECTRA 3D, dinotefuran is partially absorbed through the dog’s skin leading to systemic exposure but this absorption into the body is not relevant for the efficacy.

Pyriproxyfen absorption from VECTRA 3D through the skin may also occur.

Permethrin from VECTRA 3D is not absorbed. In the pharmacokinetic study, the plasma levels remained systematically under the limit of quantification.

If VECTRA 3D gets in my eyes or on my skin, what should I do?

If in the eyes, hold eye open and rinse slowly and gently with water for 15 to 20 minutes. Remove contact lenses, if present, after the first 15 minutes, then continue rinsing. Contact your doctor for treatment advice.

If swallowed, call a doctor immediately for treatment advice.

If on the skin, take off contaminated clothes. Rinse the skin immediately with plenty of water for 15 to 20 minutes. Call a doctor immediately for treatment advice.

Is my cat at risk if I use VECTRA 3D on my dog?

To be at risk, your cat needs to ingest or to be in contact with VECTRA 3D. This can occur if your cat grooms a treated dog and if the application site is not dry yet. To prevent oral exposure of your cat to VECTRA 3D, we recommend keeping treated dogs away from cats after treatment until the application site is dry. Cats should not be allowed to groom dogs at the application site until the product has dried. Seek veterinary advice immediately if this occurs.

Is VECTRA 3D toxic to wildlife?

Yes. VECTRA 3D is a veterinary medicine and it is toxic to aquatic organisms and arthropods. For this reason:
- Treated dogs should not be allowed to enter surface water (rivers, streams, sea) for 48 hours after treatment.
- VECTRA 3D should not be allowed to enter surface waters.
- Any unused VECTRA 3D or VECTRA 3D waste materials should be disposed of in accordance with local requirements.

Does VECTRA 3D control other parasites besides fleas and ticks?

Yes. VECTRA 3D is proven to protect your dog for a full month from other major vectors such as mosquitoes and stable flies.

Does VECTRA 3D control immature stages of fleas and ticks?

Yes. Immature stages of ticks are more susceptible to acaricide than adult forms. They are easier to kill.

VECTRA 3D contains the Insect Growth Regulator pyriproxyfen. It makes VECTRA 3D truly effective against all immature stages of fleas for 2 months after administration.